Question 1

What is AxImmune Inc. developing?

Accepted Answer

AxImmune Inc. is developing clinical stage immuno-oncology (IO) technology in-licensed from Colorado State University (CSU) and Axon Connected, LLC. Their lead candidate, AX-101, is a potent immuno-modulatory agent that works synergistically with immune checkpoint inhibitors (ICIs) to improve outcomes and potentially expand the cancers treatable with ICI drugs.

Question 2

What have the animal studies for AX-101 shown?

Accepted Answer

Animal studies, including those conducted at CSU and respected independent testing labs, have indicated that AX-101 is a potent immuno-modulatory agent that works synergistically with immune checkpoint inhibitors (ICIs), such as Keytruda, Yervoy, and Opdivo. The co-therapy of AX-101 and ICI drugs has resulted in improved outcomes, including increased cures, greater tumor growth inhibition, and immunity to re-challenge with the same cancer, particularly in the case of melanoma.

Question 3

What have the previous human trials with AX-101 shown?

Accepted Answer

Previous AX-101 single agent human trials have shown no significant drug-related adverse effects and strong anti-tumor activity for patients with functioning immune systems. It is anticipated that the co-therapy of AX-101 and ICI drugs may increase the number of patients who achieve complete recovery and exhibit immunity against recurrence of the same cancer.

Question 4

What is the current status of AxImmune's preclinical testing?

Accepted Answer

AxImmune anticipates completion of preclinical testing for AX-101 in Q2 2019. Following the completion of preclinical testing, AxImmune intends to file an Investigational New Drug (IND) application with the FDA and anticipates commencing clinical trials in Q4 2019. Plans are underway to conduct these clinical trials at multiple sites.

Question 5

Who has joined AxImmune's Medical and Scientific Advisory Board?

Accepted Answer

The strong immuno-modulatory action and synergistic effects of AX-101 with ICI drugs have attracted an impressive group of key opinion leaders to join AxImmune's Medical and Scientific Advisory Board.

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What is AxImmune Inc. developing?

What have the animal studies for AX-101 shown?

What have the previous human trials with AX-101 shown?

What is the current status of AxImmune's preclinical testing?

Who has joined AxImmune's Medical and Scientific Advisory Board?

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